Cyclobenzaprine: MedlinePlus Drug Information

This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 3 Sep 2023), Cerner Multum™ (updated 28 Aug 2023), ASHP (updated 10 Aug 2023) and others. Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice.

Cyclobenzaprine medications are not DEA Scheduled drugs and, therefore, the potential for misuse and dependence with Flexeril is considered to be relatively low. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Abuse of muscle relaxants alone is uncommon; often, it involves other substances. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, flexeril painkiller dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Cyclobenzaprine is used to help relax certain muscles in your body. It helps relieve pain, stiffness, and discomfort caused by strains, sprains, or injuries to your muscles.

• The efficacy of FLEXERIL 5 mg was demonstrated in two seven-day, double-blind, controlled clinical trials enrolling 1405 patients.
• Flexeril may also be used for purposes not listed in this medication guide.
• Use of a medication taper may be warranted for chronic-use patients.
• Signs and symptoms of toxicity may develop rapidly after cyclobenzaprine overdose; therefore, hospital monitoring is required as soon as possible.
• Do not take this drug again if you’ve ever had an allergic reaction to it.
• In two case reports, the authors described patients who quickly developed serotonin syndrome after initiating cyclobenzaprine in the short term. Check on addiction treatment for alcoholism.

Cyclobenzaprine usually begins working about one hourafter it is ingested, relaxing muscles and relieving muscle spasms. Formulations include immediate-release and extended-release. If you are prescribed cyclobenzaprine, follow your healthcare provider’s directions for how to take it. It works by blocking nerve impulses (or pain sensations) that are sent to your brain. Cyclobenzaprine is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.

Cyclobenzaprine

It is also worth noting that the term “global improvement” is nebulously defined in many, if not all, of the included studies. Importantly, this outcome measure does not appear to include an integration of the adverse effects of cyclobenzaprine into the assessment of overall benefit. If you’re taking Flexeril non-medically for a high—with or without other drugs—treatment for substance abuse can prevent you from suffering a dangerous overdose. The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. Know more on, rehab near me

The incidence of drowsiness, the most frequent adverse reaction, was similar with both drugs. Eight double-blind controlled clinical studies were performed in 642 patients comparing FLEXERIL 10 mg, diazepam, and placebo. Muscle spasm, local pain and tenderness, limitation of motion, and restriction in activities of daily living were evaluated. In three of these studies there was a significantly greater improvement with FLEXERIL than with diazepam, while in the other studies the improvement following both treatments was comparable. When certain drugs are used with cyclobenzaprine, they may cause more severe side effects such as increased drowsiness or sedation.

In a pharmacokinetic study of sixteen subjects with hepatic impairment (15 mild, 1 moderate per Child-Pugh score), both AUC and Cmax were approximately double the values seen in the healthy control group. Based on the findings, FLEXERIL should be used with caution in subjects with mild hepatic impairment starting with the 5 mg dose and titrating slowly upward. Due to the lack of data in subjects with more severe hepatic insufficiency, the use of FLEXERIL in subjects with moderate to severe impairment is not recommended. In order to protect against the rare but potentially critical manifestations described above, obtain an ECG and immediately initiate cardiac monitoring.

Pharmacotherapy of chronic orofacial pain

For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding.

Flexeril Addiction And Abuse – Addiction Center

Flexeril Addiction And Abuse.

Posted: Mon, 17 Apr 2023 07:00:00 GMT [source]

Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. Do not stand or sit up quickly, especially if you are an older patient. Alcohol may interfere with the effect of this medication. You may report side effects to your national health agency. This is not a list of all drugs or health problems that interact with this drug.

One of the publications included in this review was available only in abstract form, and another was a difficult-to-access meta-analysis of 20 unpublished trials. These two publications constituted roughly 66% of participants in the review. Neither publication represented studies for which original peer-reviewed data were available. Make your tax-deductible gift and be a part of the cutting-edge research and care that’s changing medicine. You’ll soon start receiving the latest Mayo Clinic health information you requested in your inbox. The presence of discontinuation symptoms alone is not indicative of addiction.